Income statement, balance sheet and cash flow statement for the last 3 fiscal years, taken from the XBRL data Septerna, Inc. files with the SEC in its annual reports.
In USD millions, except per-share amounts. Outflows in the cash flow statement are negative.
Income statement
FY2024
FY2024
FY2025
Revenue
0.15
1.08
46
Research and development
36
65.3
97.6
General and administrative
9.72
16.6
29.2
Operating expenses
-1.92
81.9
114
Operating income
2.08
-80.8
-68.3
Interest income
2.79
8.62
19.5
Other non-operating income
2.8
8.53
19.4
Pre-tax income
-48.9
-72.3
-48.9
Income tax
0.69
-0.5
0.01
Net income
4.18
-71.8
-48.9
EBITDA
2.88
-79.4
-66.7
EPS, basic
0.29
-7.26
-1.10
EPS, diluted
0.29
-7.26
-1.10
Shares, basic (weighted)
1.93
9.89
44.3
Shares, diluted (weighted)
2.18
9.89
44.3
Balance sheet
FY2024
FY2024
FY2025
Cash and equivalents
88.5
238
121
Short-term investments
0
113
270
Receivables
0.15
0.17
10.4
Other current assets
0.09
0.24
1.15
Total current assets
113
357
411
Property, plant and equipment
4.67
5.09
4.43
Lease right-of-use assets
12.5
23.6
21.5
Long-term investments
0
69.9
158
Other non-current assets
0.1
0.27
0.82
Total assets
131
457
596
Accounts payable
2.64
3.2
10.3
Accrued liabilities
4.28
7.8
12.2
Deferred revenue
0
62.3
Total current liabilities
6.91
12.8
86.9
Lease liabilities
12.6
23.6
21.4
Other non-current liabilities
0.55
0.03
0
Total liabilities
20
36.5
214
Paid-in capital
8.2
538
549
Retained earnings
-46.6
-118
-167
Other comprehensive income
0
0.06
0.62
Shareholders' equity
-38.4
420
382
Total equity
-38.4
420
382
Total liabilities and equity
131
457
596
Shares outstanding
3.17
44.4
44.8
Cash flow statement
FY2024
FY2024
FY2025
Net income
4.18
-71.8
-48.9
Depreciation and amortization
0.8
1.4
1.6
Stock-based compensation
1.62
3.15
8.48
Deferred income tax
0.49
-0.49
0
Change in receivables
-0.15
-0.02
-10.2
Change in payables
-0.65
0.72
6.6
Cash from operations
-38.7
-67.5
110
Capital expenditures
-2.88
-2.1
-0.52
Purchases of investments
0
-213
-451
Sales and maturities of investments
0
32.3
Cash from investing
22.1
-161
-229
Stock issued
0
0.05
0.97
Cash from financing
74.5
378
1.69
Net change in cash
57.9
150
-117
Free cash flow
-41.6
-69.6
110
Income taxes paid
0.08
0.23
0
Key metrics
Worked out from the statements above. Latest values use the trailing twelve months to June 30, 2026; growth uses fiscal years. Valuation uses the share price of $37.77 on September 25, 2026.
Profitability
Metric
Value
How it is calculated
Operating margin
-44.0%
Operating income / revenue.
EBITDA margin
-42.4%
EBITDA (operating income + depreciation and amortization) / revenue.
Pre-tax margin
-23.2%
Pre-tax income / revenue.
Net margin
-24.5%
Net income / revenue.
FCF margin
106.3%
Free cash flow (cash from operations - capital expenditures) / revenue.
Operating cash flow margin
107.2%
Cash from operations / revenue.
Return on equity (ROE)
-6.3%
Net income / average shareholders' equity (opening and closing). Not shown when equity is negative.
Return on assets (ROA)
-4.3%
Net income / average total assets.
Return on invested capital (ROIC)
-11.4%
Approximation: operating income x (1 - tax rate) / average (total debt + equity - cash). Tax rate is the effective rate when between 0% and 50%, else 21%.
R&D / revenue
122.2%
Research and development expense / revenue.
Stock-based pay / revenue
16.5%
Stock-based compensation (from the cash flow statement) / revenue.
Capex / revenue
0.9%
Capital expenditures / revenue.
D&A / revenue
1.6%
Depreciation and amortization / revenue.
Growth
Metric
Value
How it is calculated
Revenue growth, 1y
4,175.0%
Revenue vs the same period a year earlier. Only from a positive base.
Book value growth, 1y
-9.1%
Book value vs the same period a year earlier. Only from a positive base.
Total assets growth, 1y
30.6%
Total assets vs the same period a year earlier. Only from a positive base.
Share count change, 1y
347.5%
Change in diluted weighted shares vs a year earlier. Negative means buybacks shrank the share count; positive means dilution.
Balance sheet health
Metric
Value
How it is calculated
Current ratio
4.99x
Current assets / current liabilities.
Quick ratio
4.85x
(Cash + short-term investments + receivables) / current liabilities.
Cash ratio
4.69x
(Cash + short-term investments) / current liabilities.
Capital expenditures / cash from operations, when that is positive.
Per share
Metric
Value
How it is calculated
EPS, diluted
-$0.54
Net income per diluted share, as reported (split-adjusted). Over the last twelve months: the four quarters summed, or net income / latest diluted shares when a quarter has no reported EPS.
Revenue per share
$2.20
Revenue / diluted weighted shares.
FCF per share
$2.33
Free cash flow / diluted weighted shares.
Operating cash flow per share
$2.35
Cash from operations / diluted weighted shares.
Book value per share
$8.47
Shareholders' equity / shares outstanding (diluted weighted shares when not reported).
Market cap + total debt - cash - short-term investments.
P/S
17.8x
Market cap / revenue.
P/B
4.56x
Market cap / shareholders' equity. Only when equity is positive.
Price / tangible book
4.56x
Market cap / tangible book value, when positive.
P/FCF
16.8x
Market cap / free cash flow. Only when free cash flow is positive.
P/OCF
16.6x
Market cap / cash from operations, when positive.
EV/Sales
14.1x
Enterprise value / revenue.
EV/FCF
13.2x
Enterprise value / free cash flow, when both are positive.
FCF yield
6.0%
Free cash flow / market cap.
Earnings yield
-1.4%
Net income / market cap (the inverse of P/E).
What was Septerna, Inc.'s revenue in fiscal 2025?
Septerna, Inc. reported revenue of $46.0M for fiscal 2025, 4,174.5% higher than the year before.
Was Septerna, Inc. profitable in fiscal 2025?
No. It reported a net loss of $48.9M.
How much free cash flow did Septerna, Inc. generate in fiscal 2025?
Cash from operations of $110.2M minus capital expenditures of $518.0K left free cash flow of $109.7M.
Source: SEC EDGAR XBRL company facts. Where a company tags only year-to-date figures, quarters are worked out as differences. Where a line is not tagged it is left empty, never estimated.