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Vertex Pharmaceuticals Inc / MA (VRTX)

Vertex Pharmaceuticals Inc / MA brought in $12.6B of revenue over the twelve months to June 30, 2026, up 10.2% from a year earlier. Net income was $4.4B, a net margin of 35.0%. Operating cash flow minus capital spending left $3.2B of free cash flow in fiscal 2025. At June 30, 2026 it held $6.1B in cash. Its latest periodic report to the SEC is the quarterly report (10-Q) filed on August 4, 2026.

Free, no password. An email when VRTX files with the SEC.

Price
$511.28
+0.24% on the day · October 12, 2026
52-week range $402.58 to $560.25
Market cap
$129.6B
Revenue (last 12 months)
$12.6B
+10.2% year on year
Net margin
35.0%
P/E
33.4
on FY2025 diluted EPS

Key facts about Vertex Pharmaceuticals Inc / MA

Net worth
Vertex Pharmaceuticals Inc / MA has a market value (market cap) of $129.6B at the latest share price, and shareholders' equity of $20.2B on its balance sheet at June 30, 2026. A company's "net worth" usually means one of these: what the market pays for all its shares, or its assets minus its liabilities.
Revenue and profit
In fiscal 2025 revenue was $12B (+8.9% year on year), with net income of $4B. Over the 12 months to June 30, 2026: revenue $12.6B, net income $4.4B.
Cash flow
In fiscal 2025 operations brought in $3.6B of cash; after $437.6M of capital spending, free cash flow was $3.2B.
Latest report
The latest periodic report (quarterly report, 10-Q) was filed with the SEC on August 4, 2026 and covers the period to June 30, 2026. Open on SEC EDGAR
Next earnings report
Vertex Pharmaceuticals Inc / MA's next report is expected around November 2, 2026. That is an estimate from its filing rhythm, not a date the company has announced.

What Vertex Pharmaceuticals Inc / MA does

Vertex Pharmaceuticals develops and commercializes small molecule drugs and gene therapies. The company is best known for developing cystic fibrosis treatments, including Trikafta and Kalydeco. Its therapies are prescribed to patients and sold through specialty pharmacies and distributors. Its shares trade on NASDAQ under the ticker VRTX.

Revenue and profit by year

Revenue
FY18: $3B $3B FY18FY19: $4.2B $4.2B FY19FY20: $6.2B $6.2B FY20FY21: $7.6B $7.6B FY21FY22: $8.9B $8.9B FY22FY23: $9.9B $9.9B FY23FY24: $11B $11B FY24FY25: $12B $12B FY25
Net income
FY18: $2.1B $2.1B FY18FY19: $1.2B $1.2B FY19FY20: $2.7B $2.7B FY20FY21: $2.3B $2.3B FY21FY22: $3.3B $3.3B FY22FY23: $3.6B $3.6B FY23FY24: -$535.6M -$535.6M FY24FY25: $4B $4B FY25

Fiscal years as reported in annual reports. Amounts in USD.

Key figures

Fiscal yearRevenueOperating incomeNet incomeDiluted EPSFree cash flow
2025$12B$4.2B$4B$15.32$3.2B
2024$11B-$232.9M-$535.6M-$2.08-$790.3M
2023$9.9B$3.8B$3.6B$13.89$3.3B
2022$8.9B$4.3B$3.3B$12.82$3.9B
2021$7.6B$2.8B$2.3B$9.01$2.4B
2020$6.2B$2.9B$2.7B$10.29$3B

Earnings: every quarter and the next report date

Full financial statements: income, balance sheet and cash flow

Next report expected around November 2, 2026.

Estimated from its filing rhythm: 52 weeks after its report of November 3, 2025. Not a date the company has announced. See the report calendar · Earnings, quarter by quarter

Where VRTX ranks in Health care

Revenue$12B
#42 of 751 in Health care · Top 5%
Revenue growth+8.9%
#297 of 532 in Health care · Bottom 44%
Net margin32.9%
#26 of 544 in Health care · Top 5%
Free cash flow margin26.6%
#31 of 490 in Health care · Top 6%

Latest fiscal year of every company in the sector with the figure reported. Revenue is ranked among companies reporting in US dollars; growth and margins among companies with at least 10 million of revenue. Health care

Latest SEC filings

What Vertex Pharmaceuticals Inc / MA has filed recently, newest first. Each links to the original document on SEC EDGAR.

  1. September 1, 2026
  2. August 4, 2026
    Quarterly report 10-Q · period to June 30, 2026Revenue rose 12% to $3.3B versus the same quarter last year; diluted EPS $4.31 versus $3.99.
  3. August 3, 2026
  4. July 7, 2026
  5. May 14, 2026
  6. May 14, 2026
  7. May 13, 2026
  8. May 13, 2026
  9. May 13, 2026
  10. May 13, 2026

Recent insider filings (Forms 3, 4 and 144): 10, the latest on September 10, 2026. Insider transactions on SEC

What is VRTX worth? A DCF from its reported cash flow

Insider trades

What the people running Vertex Pharmaceuticals Inc / MA did with its shares, from the Form 4 filings they must send the SEC within two business days.

No insider bought or sold shares on the open market in the last 90 days. The 5 reported changes were pay in shares, option exercises, shares withheld for tax or gifts.

Bought (open market)
$0
last 90 days
Sold
$0
last 90 days
DateInsiderWhatSharesPriceValueFiling
September 8, 2026 van Grunsven JasperEVP, CP and NPPO Received as pay 8,682 - - Form 4
August 28, 2026 Ambrose KristenSVP & Chief Accounting Officer Received as pay 5,000 - - Form 4
August 27, 2026 Sachs Bruce IDirector Gave as a gift 6,000 - - Form 4
July 21, 2026 Sachdev AmitEVP Chief Patient & Ext Af Off Received as pay 8,251 - - Form 4
July 21, 2026 Tatsis OuraniaEVP, Chief Reg. & Quality Off. Received as pay 8,251 - - Form 4
July 2, 2026 McKechnie DuncanEVP, Chief Commercial Officer Soldpre-planned (10b5-1) 1,541 $519.00 $799.8K Form 4
July 2, 2026 Tatsis OuraniaEVP, Chief Reg. & Quality Off. Soldpre-planned (10b5-1) 1,500 $524.99 $787.5K Form 4
July 1, 2026 Liu JoyEVP and Chief Legal Officer Soldpre-planned (10b5-1) 828 $502.71 $416.2K Form 4

All insider filings on SEC.gov · Where insiders are buying across the market

Who owns VRTX

Three views from three kinds of SEC filings, each with its own date. They overlap and are not added up.

5% holders

Anyone who owns more than 5% of a class of shares must say so on Schedule 13D (if they may seek to influence the company) or 13G (a passive holder). The latest filing of each holder is shown: 13G filings of the last 2 years, 13D of the last 3.

HolderOf classSharesFiled
Capital World Investors13G, passive 10.1% 25,695,015 May 14, 2026
Capital Research Global Investors13G, passive 8.3% 21,139,169 May 14, 2026
Vanguard Capital Management13G, passive 7.49% 19,036,076 April 30, 2026

Latest filings below 5%: The Vanguard Group 0% (March 27, 2026); Fmr LLC 3.6% (February 12, 2025).

Largest institutional holders

Positions that investment managers reported on Form 13F for the quarter ended June 30, 2026, largest first, with the change on the quarter ended March 31, 2026. Managers file 13F up to 45 days after a quarter ends. 1,754 managers reported a position.

HolderSharesValueChange on quarter
Capital World Investors26,115,014$12.97B+746,890
BlackRock, Inc.24,109,373$11.98B+139,856
Capital Research Global Investors19,490,637$9.68B-1,635,327
Vanguard Capital Management LLC16,580,713$8.24B+67,903
State Street Corp11,871,459$5.9B+141,320
Invesco Ltd.8,043,052$4B+150,441
Jpmorgan Chase & Co6,517,600$3.26B-515,556
Geode Capital Management, LLC6,017,848$2.98B-121,773
Vanguard Portfolio Management LLC4,878,987$2.42B-266,622
Capital International Investors4,695,144$2.33B-430,933
Loomis Sayles & Co L P3,920,953$1.95B-82,868
Franklin Resources Inc3,347,253$1.66B+2,796,121
Wellington Management Group Llp3,247,658$1.61B+35,069
Morgan Stanley3,242,139$1.61B+53,258
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC3,086,683$1.53B+29,287
Bank of America Corp3,039,178$1.51B+160,995
Jennison Associates LLC2,998,530$1.49B+258,471
Norges Bank2,971,681$1.48Bnew
Alliancebernstein L.P.3,019,315$1.35B-891,471
Ameriprise Financial Inc2,604,822$1.29B-28,659

Insiders

Reported holdings of insiders who filed a Form 4 in the last 12 months: the shares each one held after their latest reported transaction. This is not the total held by all insiders.

22 insiders reported holding 504,850 shares in total, about $256M at the last price.

HolderSharesAs of
Kewalramani ReshmaCEO & President, Director 98,278 February 27, 2026
Sachdev AmitEVP Chief Patient & Ext Af Off 66,512 July 21, 2026
Tatsis OuraniaEVP, Chief Reg. & Quality Off. 53,572 July 21, 2026
Wagner Charles F JrEVP, CO & FO 47,042 February 24, 2026
Sachs Bruce IDirector 39,000 August 27, 2026
Leiden Jeffrey MExecutive Chairman, Director 34,797 February 24, 2026
Altshuler DavidEVP, Chief Scientific Officer 34,477 January 22, 2026
Liu JoyEVP and Chief Legal Officer 19,131 July 1, 2026
Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. 18,432 February 25, 2026
Bozic CarmenEVP and CMO 15,337 June 26, 2026

Schedule 13D/13G filings on SEC.gov

All filings on SEC EDGAR

Questions about VRTX

What does Vertex Pharmaceuticals Inc / MA do?

Vertex Pharmaceuticals develops and commercializes small molecule drugs and gene therapies. The company is best known for developing cystic fibrosis treatments, including Trikafta and Kalydeco. Its therapies are prescribed to patients and sold through specialty pharmacies and distributors. Its shares trade on NASDAQ under the ticker VRTX.

What is Vertex Pharmaceuticals Inc / MA's net worth?

Vertex Pharmaceuticals Inc / MA has a market value (market cap) of $129.6B at the latest share price, and shareholders' equity of $20.2B on its balance sheet at June 30, 2026. A company's "net worth" usually means one of these: what the market pays for all its shares, or its assets minus its liabilities.

Is Vertex Pharmaceuticals Inc / MA profitable?

Yes. Over the twelve months to June 30, 2026 it reported net income of $4.4B on revenue of $12.6B, a net margin of 35.0%.

How much revenue does Vertex Pharmaceuticals Inc / MA make?

Over the twelve months to June 30, 2026 Vertex Pharmaceuticals Inc / MA reported revenue of $12.6B. That is 10.2% more than a year earlier.

When did Vertex Pharmaceuticals Inc / MA last report?

Its most recent periodic report is the quarterly report (10-Q) filed on August 4, 2026. It covers the period to June 30, 2026. Its newest filing of any kind is the insider trade from September 10, 2026.

When is Vertex Pharmaceuticals Inc / MA's next earnings report?

Vertex Pharmaceuticals Inc / MA's next report is expected around November 2, 2026. That is an estimate from its filing rhythm, not a date the company has announced.

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Where the numbers come from

Financial figures are the values Vertex Pharmaceuticals Inc / MA tagged in its own SEC filings (XBRL), taken from the latest filing for each period, so restatements replace older figures. Revenue, profit and cash flow are for full fiscal years unless marked as the last twelve months, which is the sum of the four most recent quarters. Where a company reports only the full year, the fourth quarter is the year minus the first three.

Prices are delayed end-of-day market data in the listing currency, and market cap moves with the price. P/E is shown only when earnings per share are positive. Nothing here is investment advice.