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NASDAQ · Health care

Puma Biotechnology, Inc. (PBYI)

Puma Biotechnology, Inc. brought in $231.8M of revenue over the twelve months to September 30, 2026, up 9.4% from a year earlier. Net income was $23.8M, a net margin of 10.3%. Operating cash flow minus capital spending left $41.7M of free cash flow in fiscal 2025. At September 30, 2026 it held $41.5M in cash. Its latest periodic report to the SEC is the quarterly report (10-Q) filed on November 9, 2026.

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Price
$8.26
-1.61% on the day · November 10, 2026
52-week range $4.58 to $11.50
Market cap
$426.4M
Revenue (last 12 months)
$231.8M
+9.4% year on year
Net margin
10.3%
P/E
13.5
on FY2025 diluted EPS

Key facts about Puma Biotechnology, Inc.

Net worth
Puma Biotechnology, Inc. has a market value (market cap) of $426.4M at the latest share price, and shareholders' equity of $146.6M on its balance sheet at September 30, 2026. A company's "net worth" usually means one of these: what the market pays for all its shares, or its assets minus its liabilities.
Revenue and profit
In fiscal 2025 revenue was $228.4M (-0.9% year on year), with net income of $31.1M. Over the 12 months to September 30, 2026: revenue $231.8M, net income $23.8M.
Cash flow
In fiscal 2025 operations brought in $41.8M of cash; after $71K of capital spending, free cash flow was $41.7M.
Latest report
The latest periodic report (quarterly report, 10-Q) was filed with the SEC on November 9, 2026 and covers the period to September 30, 2026. Open on SEC EDGAR
Next earnings report
Puma Biotechnology, Inc.'s next report is expected around February 25, 2027. That is an estimate from its filing rhythm, not a date the company has announced.

What Puma Biotechnology, Inc. does

Puma Biotechnology, Inc. is registered with the SEC under industry code SIC 2834 (Pharmaceutical Preparations). Its shares trade on NASDAQ under the ticker PBYI.

Revenue and profit by year

Revenue
FY18: $251M $251M FY18FY19: $272.3M $272.3M FY19FY20: $225.1M $225.1M FY20FY21: $253.2M $253.2M FY21FY22: $228M $228M FY22FY23: $235.6M $235.6M FY23FY24: $230.5M $230.5M FY24FY25: $228.4M $228.4M FY25
Net income
FY18: -$113.6M -$113.6M FY18FY19: -$75.6M -$75.6M FY19FY20: -$60M -$60M FY20FY21: -$29.1M -$29.1M FY21FY22: $2K $2K FY22FY23: $21.6M $21.6M FY23FY24: $30.3M $30.3M FY24FY25: $31.1M $31.1M FY25

Fiscal years as reported in annual reports. Amounts in USD.

Key figures

Fiscal yearRevenueOperating incomeNet incomeDiluted EPSFree cash flow
2025$228.4M$37.3M$31.1M$0.61$41.7M
2024$230.5M$31M$30.3M$0.62$38.9M
2023$235.6M$32.6M$21.6M$0.45$26.9M
2022$228M$23.7M$2K$0.00-$15.8M
2021$253.2M$1.3M-$29.1M-$0.72$20.7M
2020$225.1M-$30.4M-$60M-$1.52$727K

Earnings: every quarter and the next report date

Full financial statements: income, balance sheet and cash flow

Next report expected around February 25, 2027.

Estimated from its filing rhythm: 52 weeks after its report of February 26, 2026. Not a date the company has announced. See the report calendar · Earnings, quarter by quarter

Where PBYI ranks in Health care

Revenue$228.4M
#264 of 751 in Health care · Top 35%
Revenue growth-0.9%
#418 of 532 in Health care · Bottom 21%
Net margin13.6%
#88 of 544 in Health care · Top 16%
Free cash flow margin18.3%
#70 of 490 in Health care · Top 14%

Latest fiscal year of every company in the sector with the figure reported. Revenue is ranked among companies reporting in US dollars; growth and margins among companies with at least 10 million of revenue. Health care

Latest SEC filings

What Puma Biotechnology, Inc. has filed recently, newest first. Each links to the original document on SEC EDGAR.

  1. November 9, 2026
    Quarterly report 10-Q · period to September 30, 2026Revenue rose 1.1% to $55.1M versus the same quarter last year; diluted EPS $0.11 versus $0.17.
  2. November 5, 2026
  3. October 6, 2026
  4. August 6, 2026
    Quarterly report 10-Q · period to June 30, 2026Revenue rose 7.8% to $56.5M versus the same quarter last year; diluted EPS $0.16 versus $0.12.
  5. August 6, 2026
  6. June 16, 2026
  7. May 7, 2026
    Quarterly report 10-Q · period to March 31, 2026Revenue fell 2.6% to $44.8M versus the same quarter last year; diluted EPS -$0.07 versus $0.06.
  8. May 7, 2026
  9. April 28, 2026
  10. April 28, 2026

Recent insider filings (Forms 3, 4 and 144): 10, the latest on September 16, 2026. Insider transactions on SEC

What is PBYI worth? A DCF from its reported cash flow

Insider trades

What the people running Puma Biotechnology, Inc. did with its shares, from the Form 4 filings they must send the SEC within two business days.

Insiders sold $612.5K worth of shares in the last 90 days and bought none on the open market. All of the selling was pre-planned under Rule 10b5-1 trading plans.

Bought (open market)
$0
last 90 days
Sold
$612.5K
last 90 days
Net sold
67,150
$612.5K
DateInsiderWhatSharesPriceValueFiling
September 14, 2026 Cesano AlessandraDirector Exercised options 50,000 $2.93 $146.5K Form 4
September 14, 2026 Cesano AlessandraDirector Soldpre-planned (10b5-1) 62,150 $9.12 $567K Form 4
September 14, 2026 Wilson Troy EdwardDirector Soldpre-planned (10b5-1) 5,000 $9.10 $45.5K Form 4
July 6, 2026 Nougues Maximo FChief Financial Officer Soldpre-planned (10b5-1) 9,386 $8.26 $77.6K Form 4
July 6, 2026 Hunt Douglas MSee Remarks Soldpre-planned (10b5-1) 8,460 $8.26 $69.9K Form 4
July 6, 2026 Auerbach Alan HPresident and CEO, Director, 10% owner Soldpre-planned (10b5-1) 44,058 $8.26 $364.1K Form 4
June 12, 2026 Dorval AllisonDirector Soldpre-planned (10b5-1) 11,610 $7.20 $83.6K Form 4
June 12, 2026 Moyes Jay MDirector Soldpre-planned (10b5-1) 22,000 $7.22 $158.8K Form 4

All insider filings on SEC.gov · Where insiders are buying across the market

Who owns PBYI

Three views from three kinds of SEC filings, each with its own date. They overlap and are not added up.

5% holders

Anyone who owns more than 5% of a class of shares must say so on Schedule 13D (if they may seek to influence the company) or 13G (a passive holder). The latest filing of each holder is shown: 13G filings of the last 2 years, 13D of the last 3.

HolderOf classSharesFiled
Alan H. Auerbach13D, may seek influence 16% 8,648,958 October 6, 2026
Anders Hove13G, passive with 4 related filers 8% 3,940,052 February 14, 2025

Latest filings below 5%: The Vanguard Group 0% (March 27, 2026); Camber Capital Management LP 0% (February 14, 2025); Frazier Life Sciences Public Fund, L.P. 0% (February 14, 2025); Millennium Management LLC 3.9% (February 3, 2025).

Largest institutional holders

Positions that investment managers reported on Form 13F for the quarter ended June 30, 2026, largest first, with the change on the quarter ended March 31, 2026. Managers file 13F up to 45 days after a quarter ends. 161 managers reported a position.

HolderSharesValueChange on quarter
Acorn Capital Advisors, LLC4,131,299$33.5M0
BlackRock, Inc.3,804,736$30.9M+205,784
American Century Companies Inc2,319,996$18.8M+403,650
Renaissance Technologies LLC1,836,213$14.9M-106,200
Vanguard Capital Management LLC1,835,643$14.9M+17,962
Vanguard Portfolio Management LLC1,825,599$14.8M+90,950
Dimensional Fund Advisors LP1,518,014$12.3M+81,908
Geode Capital Management, LLC1,339,405$10.9M+322,063
O'Shaughnessy Asset Management, LLC1,123,783$9.1M-14,386
State Street Corp952,165$7.7M+34,575
Kennedy Capital Management LLC873,253$7.1M-16,348
Bridgeway Capital Management, LLC791,616$6.4M+16,275
Ritholtz Wealth Management749,798$6.1M-24,510
Aqr Capital Management LLC725,192$5.9M-75,002
Goldman Sachs Group Inc669,156$5.4M-563
Northern Trust Corp652,386$5.3M+10,633
Connor, Clark & Lunn Investment Management Ltd.642,946$5.2M-139,852
UBS Group AG636,761$5.2M+102,534
Millennium Management LLC602,240$4.9M-875,279
Arrowstreet Capital, Limited Partnership532,450$4.3M-5,705

Insiders

Reported holdings of insiders who filed a Form 4 in the last 12 months: the shares each one held after their latest reported transaction. This is not the total held by all insiders.

10 insiders reported holding 8,171,559 shares in total, about $67.5M at the last price.

HolderSharesAs of
Auerbach Alan HPresident and CEO, Director, 10% owner 7,261,671 July 6, 2026
Nougues Maximo FChief Financial Officer 230,637 July 6, 2026
Hunt Douglas MSee Remarks 196,841 July 6, 2026
Stuglik Brian MDirector 113,858 June 12, 2026
Dorval AllisonDirector 90,780 June 12, 2026
Miller Michael PatrickDirector 81,000 June 11, 2026
Moyes Jay MDirector 58,322 June 12, 2026
Cesano AlessandraDirector 56,700 September 14, 2026
Wilson Troy EdwardDirector 54,750 September 14, 2026
Senderowicz AdrianDirector 27,000 June 12, 2026

Schedule 13D/13G filings on SEC.gov

All filings on SEC EDGAR

Questions about PBYI

What does Puma Biotechnology, Inc. do?

Puma Biotechnology, Inc. is a company in the Health care sector, listed on NASDAQ as PBYI. Its shares trade on NASDAQ under the ticker PBYI.

What is Puma Biotechnology, Inc.'s net worth?

Puma Biotechnology, Inc. has a market value (market cap) of $426.4M at the latest share price, and shareholders' equity of $146.6M on its balance sheet at September 30, 2026. A company's "net worth" usually means one of these: what the market pays for all its shares, or its assets minus its liabilities.

Is Puma Biotechnology, Inc. profitable?

Yes. Over the twelve months to September 30, 2026 it reported net income of $23.8M on revenue of $231.8M, a net margin of 10.3%.

How much revenue does Puma Biotechnology, Inc. make?

Over the twelve months to September 30, 2026 Puma Biotechnology, Inc. reported revenue of $231.8M. That is 9.4% more than a year earlier.

When did Puma Biotechnology, Inc. last report?

Its most recent periodic report is the quarterly report (10-Q) filed on November 9, 2026. It covers the period to September 30, 2026.

When is Puma Biotechnology, Inc.'s next earnings report?

Puma Biotechnology, Inc.'s next report is expected around February 25, 2027. That is an estimate from its filing rhythm, not a date the company has announced.

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Where the numbers come from

Financial figures are the values Puma Biotechnology, Inc. tagged in its own SEC filings (XBRL), taken from the latest filing for each period, so restatements replace older figures. Revenue, profit and cash flow are for full fiscal years unless marked as the last twelve months, which is the sum of the four most recent quarters. Where a company reports only the full year, the fourth quarter is the year minus the first three.

Prices are delayed end-of-day market data in the listing currency, and market cap moves with the price. P/E is shown only when earnings per share are positive. Nothing here is investment advice.