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DCF valuation

What is Septerna, Inc. worth?

With the base-case assumptions below, a discounted cash flow model on Septerna, Inc.'s reported free cash flow gives $83.78 per share. The share price was $37.77 on September 25, 2026, 55% below that value.

Inputs from the filings

Free cash flow, fiscal 2025
$109.7M
Average free cash flow, last 3 years
-$501K
Cash
$84.7M
balance sheet of June 30, 2026
Debt
$0
not reported, counted as 0
Diluted shares, fiscal 2025
44,258,338
Revenue growth per year, last 1 years
30,331.1%

Three sets of assumptions

CaseGrowth yrs 1-5Growth yrs 6-10After year 10Discount rateValue per shareValue vs price
Bear10.0%6.0%2.0%10.0%$51.66+37%
Base15.0%9.0%2.5%9.0%$83.78+122%
Bull20.0%11.5%3.0%8.0%$143.60+280%

Sensitivity: base case value per share

Discount rate down the side, growth after year 10 across the top. Everything else as in the base case.

1.5%2.0%2.5%3.0%3.5%
7.0%$108.11$115.69$124.96$136.55$151.44
8.0%$89.83$94.75$100.57$107.54$116.07
9.0%$76.54$79.90$83.78$88.31$93.66
10.0%$66.46$68.85$71.56$74.66$78.23
11.0%$58.57$60.33$62.29$64.49$66.99

Where the presets come from

Base: years 1 to 5 grow at Septerna, Inc.'s revenue growth rate over the last 1 fiscal years (30,331.1% a year), held between -5% and 15%. Years 6 to 10 grow halfway between that and the long-run rate of 2.5%. Future cash is discounted at 9% a year.

Bear: 5 points less growth, 2% long-run growth, 10% discount rate. Bull: 5 points more growth (at most 25%), 3% long-run growth, 8% discount rate.

Value per share = (present value of 10 years of free cash flow + present value of everything after + cash - debt) / diluted shares.

This is a model run on assumptions, not a recommendation or a price target. Small changes in the discount rate or growth move the result a lot, as the table above shows. Change them yourself in the calculator.

Adjust the assumptions

Move the sliders for growth, long-run growth and discount rate, or switch to average free cash flow, and see the value per share change.

Adjust the assumptions

Septerna, Inc. company page