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NASDAQ · Health care

Protagonist Therapeutics, Inc (PTGX)

Protagonist Therapeutics, Inc brought in $282M of revenue over the twelve months to June 30, 2026, up 34.8% from a year earlier. Net income was $82.9M, a net margin of 29.4%. Operating cash flow minus capital spending left $56.1M of free cash flow in fiscal 2025. At June 30, 2026 it held $420.1M in cash. Its latest periodic report to the SEC is the quarterly report (10-Q) filed on August 5, 2026.

Price
$141.86
+3.29% on the day · September 25, 2026
52-week range $62.24 to $160.81
Market cap
$9.2B
Revenue (last 12 months)
$282M
+34.8% year on year
Net margin
29.4%

What Protagonist Therapeutics, Inc does

Protagonist Therapeutics, Inc is registered with the SEC under industry code SIC 2834 (Pharmaceutical Preparations). Its shares trade on NASDAQ under the ticker PTGX.

Revenue and profit by year

Revenue
FY18: $30.9M $30.9M FY18FY19: $231K $231K FY19FY20: $28.6M $28.6M FY20FY21: $27.4M $27.4M FY21FY22: $26.6M $26.6M FY22FY23: $60M $60M FY23FY24: $434.4M $434.4M FY24FY25: $46M $46M FY25
Net income
FY18: -$38.9M -$38.9M FY18FY19: -$77.2M -$77.2M FY19FY20: -$66.2M -$66.2M FY20FY21: -$125.6M -$125.6M FY21FY22: -$127.4M -$127.4M FY22FY23: -$79M -$79M FY23FY24: $275.2M $275.2M FY24FY25: -$130.1M -$130.1M FY25

Fiscal years as reported in annual reports. Amounts in USD.

Key figures

Fiscal yearRevenueOperating incomeNet incomeDiluted EPSFree cash flow
2025$46M-$158.1M-$130.1M-$2.05$56.1M
2024$434.4M$252.8M$275.2M$4.23$182.8M
2023$60M-$93.7M-$79M-$1.39-$70.8M
2022$26.6M-$131.4M-$127.4M-$2.60-$108.9M
2021$27.4M-$125.8M-$125.6M-$2.71-$109M
2020$28.6M-$64.5M-$66.2M-$1.92-$73M
Next report expected around November 5, 2026.

Estimated from its filing rhythm: about 92 days after its last report of August 5, 2026, its usual gap. Not a date the company has announced. See the report calendar

Where PTGX ranks in Health care

Revenue$46M
#363 of 523 in Health care · Bottom 31%
Revenue growth-89.4%
#437 of 437 in Health care · Bottom 1%
Net margin-282.8%
#404 of 447 in Health care · Bottom 10%
Free cash flow margin121.9%
#3 of 408 in Health care · Top 1%

Latest fiscal year of every company in the sector with the figure reported. Revenue is ranked among companies reporting in US dollars; growth and margins among companies with at least 10 million of revenue. Health care

Latest SEC filings

What Protagonist Therapeutics, Inc has filed recently, newest first. Each links to the original document on SEC EDGAR.

  1. August 13, 2026
  2. August 7, 2026
  3. August 5, 2026
  4. August 5, 2026
  5. August 5, 2026
  6. August 5, 2026
  7. August 5, 2026
  8. August 5, 2026
  9. August 5, 2026
  10. August 5, 2026

Recent insider filings (Forms 3, 4 and 144): 10, the latest on September 10, 2026. Insider transactions on SEC

What is PTGX worth? A DCF from its reported cash flow

Insider trades

What the people running Protagonist Therapeutics, Inc did with its shares, from the Form 4 filings they must send the SEC within two business days.

Insiders sold $18.2M worth of shares in the last 90 days and bought none on the open market. All of the selling was pre-planned under Rule 10b5-1 trading plans.

Bought (open market)
$0
last 90 days
Sold
$18.2M
last 90 days
Net sold
125,000
$18.2M
DateInsiderWhatSharesPriceValueFiling
September 10, 2026 Patel Dinesh V Ph DPresident and CEO, Director Exercised options 7,278 $21.58 $157.1K Form 4
September 10, 2026 Patel Dinesh V Ph DPresident and CEO, Director Soldpre-planned (10b5-1) 7,278 $144.10 $1M Form 4
September 9, 2026 Patel Dinesh V Ph DPresident and CEO, Director Exercised options 63,548 $21.58 $1.4M Form 4
September 9, 2026 Patel Dinesh V Ph DPresident and CEO, Director Soldpre-planned (10b5-1) 63,548 $146.18 $9.3M Form 4
September 8, 2026 Patel Dinesh V Ph DPresident and CEO, Director Exercised options 54,174 $21.58 $1.2M Form 4
September 8, 2026 Patel Dinesh V Ph DPresident and CEO, Director Soldpre-planned (10b5-1) 54,174 $145.87 $7.9M Form 4
September 3, 2026 Patel Dinesh V Ph DPresident and CEO, Director Gave as a gift 510 - - Form 4

All insider filings on SEC.gov · Where insiders are buying across the market

All filings on SEC EDGAR

Questions about PTGX

What does Protagonist Therapeutics, Inc do?

Protagonist Therapeutics, Inc is registered with the SEC under industry code SIC 2834 (Pharmaceutical Preparations). Its shares trade on NASDAQ under the ticker PTGX.

Is Protagonist Therapeutics, Inc profitable?

Yes. Over the twelve months to June 30, 2026 it reported net income of $82.9M on revenue of $282M, a net margin of 29.4%.

How much revenue does Protagonist Therapeutics, Inc make?

Over the twelve months to June 30, 2026 Protagonist Therapeutics, Inc reported revenue of $282M. That is 34.8% more than a year earlier.

When did Protagonist Therapeutics, Inc last report?

Its most recent periodic report is the quarterly report (10-Q) filed on August 5, 2026. It covers the period to June 30, 2026. Its newest filing of any kind is the insider trade from September 10, 2026.

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Where the numbers come from

Financial figures are the values Protagonist Therapeutics, Inc tagged in its own SEC filings (XBRL), taken from the latest filing for each period, so restatements replace older figures. Revenue, profit and cash flow are for full fiscal years unless marked as the last twelve months, which is the sum of the four most recent quarters. Where a company reports only the full year, the fourth quarter is the year minus the first three.

Prices are delayed end-of-day market data in the listing currency, and market cap moves with the price. P/E is shown only when earnings per share are positive. Nothing here is investment advice.