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CytomX Therapeutics, Inc. (CTMX)

CytomX Therapeutics, Inc. brought in $14M of revenue over the twelve months to September 30, 2026, down 87.7% from a year earlier. It posted a net loss of $85.4M. In fiscal 2025 capital spending exceeded operating cash flow by $75.8M. At September 30, 2026 it held $34M in cash. Its latest periodic report to the SEC is the quarterly report (10-Q) filed on November 5, 2026.

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Price
$1.98
-9.59% on the day · November 9, 2026
52-week range $1.95 to $8.21
Market cap
$431.4M
Revenue (last 12 months)
$14M
-87.7% year on year
Net margin
-609.0%

Key facts about CytomX Therapeutics, Inc.

Net worth
CytomX Therapeutics, Inc. has a market value (market cap) of $431.4M at the latest share price, and shareholders' equity of $284.9M on its balance sheet at September 30, 2026. A company's "net worth" usually means one of these: what the market pays for all its shares, or its assets minus its liabilities.
Revenue and profit
In fiscal 2025 revenue was $76.2M (-44.8% year on year), with a net loss of $17.4M. Over the 12 months to September 30, 2026: revenue $14M, net loss $85.4M.
Cash flow
In fiscal 2025 operations used $75.6M of cash.
Latest report
The latest periodic report (quarterly report, 10-Q) was filed with the SEC on November 5, 2026 and covers the period to September 30, 2026. Open on SEC EDGAR
Next earnings report
CytomX Therapeutics, Inc.'s next report is expected around March 15, 2027. That is an estimate from its filing rhythm, not a date the company has announced.

What CytomX Therapeutics, Inc. does

CytomX Therapeutics, Inc. is registered with the SEC under industry code SIC 2834 (Pharmaceutical Preparations). Its shares trade on NASDAQ under the ticker CTMX.

Revenue and profit by year

Revenue
FY18: $59.5M $59.5M FY18FY19: $26.9M $26.9M FY19FY20: $68.4M $68.4M FY20FY21: $37.3M $37.3M FY21FY22: $53.2M $53.2M FY22FY23: $101.2M $101.2M FY23FY24: $138.1M $138.1M FY24FY25: $76.2M $76.2M FY25
Net income
FY18: -$84.6M -$84.6M FY18FY19: -$132.8M -$132.8M FY19FY20: -$64.8M -$64.8M FY20FY21: -$115.9M -$115.9M FY21FY22: -$99.3M -$99.3M FY22FY23: -$569K -$569K FY23FY24: $31.9M $31.9M FY24FY25: -$17.4M -$17.4M FY25

Fiscal years as reported in annual reports. Amounts in USD.

Key figures

Fiscal yearRevenueOperating incomeNet incomeDiluted EPSFree cash flow
2025$76.2M-$22.4M-$17.4Mn/a-$75.8M
2024$138.1M$25M$31.9Mn/a-$86.5M
2023$101.2M-$6.5M-$569Kn/a-$56.9M
2022$53.2M-$101.3M-$99.3Mn/a-$112.5M
2021$37.3M-$116M-$115.9Mn/a-$120.6M
2020$68.4M-$80.5M-$64.8Mn/a$3M

Earnings: every quarter and the next report date

Full financial statements: income, balance sheet and cash flow

Next report expected around March 15, 2027.

Estimated from its filing rhythm: 52 weeks after its report of March 16, 2026. Not a date the company has announced. See the report calendar · Earnings, quarter by quarter

Where CTMX ranks in Health care

Revenue$76.2M
#353 of 751 in Health care · Top 47%
Revenue growth-44.8%
#518 of 532 in Health care · Bottom 3%
Net margin-22.8%
#334 of 544 in Health care · Bottom 39%
Free cash flow margin-99.5%
#405 of 490 in Health care · Bottom 17%

Latest fiscal year of every company in the sector with the figure reported. Revenue is ranked among companies reporting in US dollars; growth and margins among companies with at least 10 million of revenue. Health care

Latest SEC filings

What CytomX Therapeutics, Inc. has filed recently, newest first. Each links to the original document on SEC EDGAR.

  1. November 5, 2026
  2. November 5, 2026
    Quarterly report 10-Q · period to September 30, 2026Revenue fell 72% to $1.7M versus the same quarter last year; net loss of $20M.
  3. October 28, 2026
  4. August 14, 2026
  5. August 14, 2026
  6. August 7, 2026
  7. August 6, 2026
  8. August 6, 2026
  9. August 6, 2026
    Quarterly report 10-Q · period to June 30, 2026Revenue fell 92% to $1.4M versus the same quarter last year; net loss of $20.7M.
  10. August 3, 2026

Recent insider filings (Forms 3, 4 and 144): 10, the latest on October 16, 2026. Insider transactions on SEC

Insider trades

What the people running CytomX Therapeutics, Inc. did with its shares, from the Form 4 filings they must send the SEC within two business days.

No insider trades were reported in the last 90 days.

Bought (open market)
$0
last 90 days
Sold
$0
last 90 days
DateInsiderWhatSharesPriceValueFiling
August 3, 2026 Carvajal AlejandraChief Legal Officer Received as pay 100,000 - - Form 4
June 15, 2026 Ogden ChristopherChief Financial Officer Sold 1,624 $3.05 $5K Form 4
March 17, 2026 Ogden ChristopherChief Financial Officer Sold 19,323 $6.42 $124.1K Form 4
March 17, 2026 Belvin MarciaSVP, Chief Scientific Officer Sold 31,492 $6.42 $202.3K Form 4
March 17, 2026 McCarthy Sean A.CEO, Director Soldpre-planned (10b5-1) 118,969 $6.42 $764.1K Form 4
March 17, 2026 Chu Yu-WayeChief Medical Officer Sold 21,279 $6.42 $136.7K Form 4
February 2, 2026 McCarthy Sean A.CEO, Director Received as pay 210,000 - - Form 4
February 2, 2026 Ogden ChristopherChief Financial Officer Received as pay 90,000 - - Form 4

All insider filings on SEC.gov · Where insiders are buying across the market

Who owns CTMX

Three views from three kinds of SEC filings, each with its own date. They overlap and are not added up.

5% holders

Anyone who owns more than 5% of a class of shares must say so on Schedule 13D (if they may seek to influence the company) or 13G (a passive holder). The latest filing of each holder is shown: 13G filings of the last 2 years, 13D of the last 3.

HolderOf classSharesFiled
Fmr LLC13G, passive with 1 related filers 14.6% 24,688,109 February 5, 2026
Kynam Capital Management, LP13G, passive with 2 related filers 9.96% 0 August 14, 2026
Patrick G. Enright13G, passive with 5 related filers 7% 15,288,461 May 15, 2026
Bank of America Corp13G, passive 5.4% 11,867,012 October 28, 2026

Latest filings below 5%: Point72 Asset Management, L.P. 3.6% (August 14, 2026); Venrock Healthcare Capital Partners III, L.P. 4.6% (May 15, 2026); Perceptive Advisors LLC 4.6% (May 15, 2026); Seven Fleet Master Fund LP 0.5% (May 15, 2026); The Vanguard Group 0% (March 26, 2026).

Largest institutional holders

Positions that investment managers reported on Form 13F for the quarter ended June 30, 2026, largest first, with the change on the quarter ended March 31, 2026. Managers file 13F up to 45 days after a quarter ends. 179 managers reported a position.

HolderSharesValueChange on quarter
Fmr LLC32,714,937$122.7M+759,300
Kynam Capital Management, LP21,703,093$81.4M+6,690,000
BlackRock, Inc.17,559,822$65.8M+12,331,542
Bank of America Corp15,082,617$56.6M+4,879,832
State Street Corp11,747,236$44.1M+6,083,828
Perceptive Advisors LLC10,439,185$39.1M+340,361
Vanguard Capital Management LLC8,525,457$32M-207,661
Point72 Asset Management, L.P.7,811,033$29.3M-64,357
Wellington Management Group Llp5,168,961$19.4M+1,585,976
Venrock Adviser, LLC4,982,124$18.7M-5,000,000
Baker Bros. Advisors LP4,975,826$18.7M0
Geode Capital Management, LLC4,678,716$17.5M+2,612,104
Elmind Capital, LP4,550,000$17.1M0
Nextech Invest Ltd.4,449,932$16.7M0
Two Sigma Investments, LP4,132,643$15.5M+1,422,487
Eversept Partners, LP3,558,497$13.3M+369,983
UBS Group AG3,468,359$13M+348,204
Siren, L.L.C.3,457,711$13M0
ADAR1 Capital Management, LLC3,365,118$12.6M-45,072
Citadel Advisors LLC3,110,509$11.7M-2,295,684

Insiders

Reported holdings of insiders who filed a Form 4 in the last 12 months: the shares each one held after their latest reported transaction. This is not the total held by all insiders.

6 insiders reported holding 1,984,452 shares in total, about $3.9M at the last price.

HolderSharesAs of
McCarthy Sean A.CEO, Director 1,078,922 March 17, 2026
Belvin MarciaSVP, Chief Scientific Officer 300,760 March 17, 2026
Ogden ChristopherChief Financial Officer 295,324 June 15, 2026
Chu Yu-WayeChief Medical Officer 189,446 March 17, 2026
Carvajal AlejandraChief Legal Officer 100,000 August 3, 2026
Lester RachaelChief Business Officer 20,000 February 2, 2026

Schedule 13D/13G filings on SEC.gov

All filings on SEC EDGAR

Questions about CTMX

What does CytomX Therapeutics, Inc. do?

CytomX Therapeutics, Inc. is a company in the Health care sector, listed on NASDAQ as CTMX. Its shares trade on NASDAQ under the ticker CTMX.

What is CytomX Therapeutics, Inc.'s net worth?

CytomX Therapeutics, Inc. has a market value (market cap) of $431.4M at the latest share price, and shareholders' equity of $284.9M on its balance sheet at September 30, 2026. A company's "net worth" usually means one of these: what the market pays for all its shares, or its assets minus its liabilities.

Is CytomX Therapeutics, Inc. profitable?

No. Over the twelve months to September 30, 2026 it reported a net loss of $85.4M on revenue of $14M.

How much revenue does CytomX Therapeutics, Inc. make?

Over the twelve months to September 30, 2026 CytomX Therapeutics, Inc. reported revenue of $14M. That is 87.7% less than a year earlier.

When did CytomX Therapeutics, Inc. last report?

Its most recent periodic report is the quarterly report (10-Q) filed on November 5, 2026. It covers the period to September 30, 2026.

When is CytomX Therapeutics, Inc.'s next earnings report?

CytomX Therapeutics, Inc.'s next report is expected around March 15, 2027. That is an estimate from its filing rhythm, not a date the company has announced.

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Where the numbers come from

Financial figures are the values CytomX Therapeutics, Inc. tagged in its own SEC filings (XBRL), taken from the latest filing for each period, so restatements replace older figures. Revenue, profit and cash flow are for full fiscal years unless marked as the last twelve months, which is the sum of the four most recent quarters. Where a company reports only the full year, the fourth quarter is the year minus the first three.

Prices are delayed end-of-day market data in the listing currency, and market cap moves with the price. P/E is shown only when earnings per share are positive. Nothing here is investment advice.